Pediatric Library

Presentations | Reference Library | Videos | Newsletter | Pamphlets

 

Click here to view a special Pediatric GIST edition of the LRG newsletter!

 

Click here to view a poster from the NIH Pediatric & Wildtype GIST clinic!

Webcast

 

Dr. Lee Helman

Pediatric GIST: Breaking New Ground
Presenters: Dr. Lee Helman, Director of the Pediatric Oncology Branch of the National Cancer Institute, and Dr. Alberto Pappo, Pediatric Oncologist of Texas Children's Cancer Center
Presented: April 15th, 2008 
Duration: 58 minutes

Dr. Lee Helman, the Director of the Pediatric Oncology Branch of the National Cancer Institute, and Dr. Alberto Pappo, Pediatric Oncologist of Texas Children’s Cancer Center, discuss a new initiative for Pediatric GIST patients.

This webcast gives you an opportunity to learn about a new NIH-based clinic scheduled for June 19, 2008. Doctors for the first time in history will come together to explore Pediatric GIST hands-on in hopes of discovering viable treatment options for these patients. Logistics about the event will be discussed by Dr. Dr. Alberto PappoHelman. Dr. Pappo will present and discuss valuable information about the genetic and clinical elements of Pediatric GIST.

We are honored to have Ashley Young and Jacqui Bromberg, Life Raft Group Pediatric GISTers and Co-chairs for the NIH Clinic Planning Committee, moderating this session (Note: Jacqui was unable to moderate this session but we want to thank her for her continuing dedication in planning the NIH clinic).

PLAY PRESENTATION

 

 

 Other Presentations 

 Dr. Katharine JanewayPediatric GIST-Genetic progession mechanisms KIT/PDGFRA transforming roles

2007 Connective Tissue Oncology Society

Gastrointestinal Stromal Tumors in Pediatric Patients MSKCC Grand Rounds

"Pediatric Gastrointestinal Stromal Tumors First NIH Pediatric Wildtype GIST Clinic Presentation, June 18, 2008

Pediatric GIST: KIT inhibitors & IGF1R-directed antibodies

Second NIH Pediatric & Wildtype GIST Clinic Presentation, January 22, 2009

♦ View the NIH Podcast: The 2nd Pediatric GIST Clinic Invitational Lecture-The IGF-1R antibody trial in patients with Pediatric and wildtype GIST

 

Pediatric GIST - The New (or forgotten) Kid on the Block

Dr. Alberto Pappo

Texas Children's Cancer Center

 

Atypical GISTs

Dr. Maria Debiec-Rychter

University of Leuven, Belgium

 

 

The NIH Pediatric & Wildtype GIST Clinic
2008 Connective Tissue Oncology Society

Dr. Su Young Kim

National Cancer Institute

Reference Library

 

1:

Pediatric gastrointestinal stromal tumors.

 

Pappo AS, Janeway KA.
Hematol Oncol Clin North Am. 2009 Feb;23(1):15-34, vii.
PMID: 19248968 [PubMed - in process]
Related Articles

 

2:

The Gist of literature on pediatric GIST: review of clinical presentation.

 

Kaemmer DA, Otto J, Lassay L, Steinau G, Klink C, Junge K, Klinge U, Schumpelick V.
J Pediatr Hematol Oncol. 2009 Feb;31(2):108-12. Review.
PMID: 19194193 [PubMed - indexed for MEDLINE]
Related Articles

 

3:

New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors.

 

Stratakis CA.
Mol Cell Endocrinol. 2009 Mar 5;300(1-2):152-157. Epub 2008 Nov 21.
PMID: 19063937 [PubMed - as supplied by publisher]
Related Articles

 

4:

Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes.

 

Liegl B, Hornick JL, Corless CL, Fletcher CD.
Am J Surg Pathol. 2009 Mar;33(3):437-46.
PMID: 19011564 [PubMed - in process]
Related Articles

 

5:

Primary gastric tumors of infancy and childhood: 54-year experience at a single institution.

 

Curtis JL, Burns RC, Wang L, Mahour GH, Ford HR.
J Pediatr Surg. 2008 Aug;43(8):1487-93.
PMID: 18675640 [PubMed - indexed for MEDLINE]
Related Articles

 

6:

Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors.

 

Agaram NP, Wong GC, Guo T, Maki RG, Singer S, Dematteo RP, Besmer P, Antonescu CR.
Genes Chromosomes Cancer. 2008 Oct;47(10):853-9.
PMID: 18615679 [PubMed - indexed for MEDLINE]
Related Articles

 

7:

What is the prognostic significance of metastatic lymph nodes in GIST?

 

Valadão M, de Mello EL, Lourenço L, Vilhena B, Romano S, Castro Ldos S.
Hepatogastroenterology. 2008 Mar-Apr;55(82-83):471-4.
PMID: 18613390 [PubMed - indexed for MEDLINE]
Related Articles

 

8:

Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors.

 

Tarn C, Rink L, Merkel E, Flieder D, Pathak H, Koumbi D, Testa JR, Eisenberg B, von Mehren M, Godwin AK.
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8387-92. Epub 2008 Jun 11.
PMID: 18550829 [PubMed - indexed for MEDLINE]
Related Articles Free article in PMC | at journal site

 

9:

Molecular characterization of pediatric gastrointestinal stromal tumors.

 

Agaram NP, Laquaglia MP, Ustun B, Guo T, Wong GC, Socci ND, Maki RG, DeMatteo RP, Besmer P, Antonescu CR.
Clin Cancer Res. 2008 May 15;14(10):3204-15.
PMID: 18483389 [PubMed - indexed for MEDLINE]
Related Articles

 

10:

Population pharmacokinetics of imatinib mesylate and its metabolite in children and young adults.

 

Menon-Andersen D, Mondick JT, Jayaraman B, Thompson PA, Blaney SM, Bernstein M, Bond M, Champagne M, Fossler MJ, Barrett JS.
Cancer Chemother Pharmacol. 2009 Jan;63(2):229-38. Epub 2008 Apr 9.
PMID: 18398615 [PubMed - indexed for MEDLINE]
Related Articles

 

11:

A 17 year-old man with an exon 11 mutation of CD-117 causing a gastrointestinal stromal tumor.

 

Bauer TM, Berlin JD.
Cancer Invest. 2008 Mar;26(2):182-4.
PMID: 18259950 [PubMed - indexed for MEDLINE]
Related Articles

 

12:

Pediatric KIT wild-type and platelet-derived growth factor receptor alpha-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors.

 

Janeway KA, Liegl B, Harlow A, Le C, Perez-Atayde A, Kozakewich H, Corless CL, Heinrich MC, Fletcher JA.
Cancer Res. 2007 Oct 1;67(19):9084-8.
PMID: 17909012 [PubMed - indexed for MEDLINE]
Related Articles Free article at journal site

 

13:

Treatment of wild-type gastrointestinal stromal tumor (WT-GIST) with imatinib and sunitinib.

 

Murray M, Hatcher H, Jessop F, Williams D, Carroll N, Bulusu R, Judson I.
Pediatr Blood Cancer. 2008 Feb;50(2):386-8.
PMID: 17729245 [PubMed - indexed for MEDLINE]
Related Articles

 

14:

Carney's triad: a 16-year follow-up.

 

Raffensperger J, Krueger R.
J Pediatr Surg. 2007 Aug;42(8):1452-3.
PMID: 17706515 [PubMed - indexed for MEDLINE]
Related Articles

 

15:

Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD.

 

Pasini B, McWhinney SR, Bei T, Matyakhina L, Stergiopoulos S, Muchow M, Boikos SA, Ferrando B, Pacak K, Assie G, Baudin E, Chompret A, Ellison JW, Briere JJ, Rustin P, Gimenez-Roqueplo AP, Eng C, Carney JA, Stratakis CA.
Eur J Hum Genet. 2008 Jan;16(1):79-88. Epub 2007 Aug 1.
PMID: 17667967 [PubMed - indexed for MEDLINE]
Related Articles Free article at journal site

 

16:

The endoscopic appearance of a gastrointestinal stromal tumor in a pediatric patient.

 

Muniyappa P, Kay M, Feinberg L, Mahajan L, Stallion A, Wyllie R.
J Pediatr Surg. 2007 Jul;42(7):1302-5.
PMID: 17618903 [PubMed - indexed for MEDLINE]
Related Articles

 

17:

Gastrointestinal stromal tumour of the duodenum in childhood: a rare case report.

 

Chiarugi M, Galatioto C, Lippolis P, Zocco G, Seccia M.
BMC Cancer. 2007 May 9;7:79.
PMID: 17490483 [PubMed - indexed for MEDLINE]
Related Articles Free article in PMC | at journal site

 

18:

A phase II study of imatinib mesylate in children with refractory or relapsed solid tumors: a Children's Oncology Group study.

 

Bond M, Bernstein ML, Pappo A, Schultz KR, Krailo M, Blaney SM, Adamson PC.
Pediatr Blood Cancer. 2008 Feb;50(2):254-8.
PMID: 17262795 [PubMed - indexed for MEDLINE]
Related Articles

 

19:

Expression of c-KIT oncoprotein in gastrointestinal stromal tumors in adults and children: guideline for diagnosis and treatment.

 

Jankulovski N, Popov Z, Bojadzieva S, Validire P, Gogusev J.
Prilozi. 2006 Dec;27(2):59-70.
PMID: 17211292 [PubMed - indexed for MEDLINE]
Related Articles

 

20:

Respiratory symptoms in a boy revealing Carney triad.

 

Delemarre L, Aronson D, van Rijn R, Bras H, Arets B, Verschuur A.
Pediatr Blood Cancer. 2008 Feb;50(2):399-401.
PMID: 17039489 [PubMed - indexed for MEDLINE]
Related Articles

 

21:

Multifocal gastrointestinal stromal tumor (GIST) of the stomach in an 11-year-old girl.

 

Park J, Rubinas TC, Fordham LA, Phillips JD.
Pediatr Radiol. 2006 Nov;36(11):1212-4. Epub 2006 Sep 13.
PMID: 16969663 [PubMed - indexed for MEDLINE]
Related Articles

 

22:

Gastrointestinal stromal tumour presenting with severe bleeding: a review of the molecular biology.

 

Towu E, Stanton M.
Pediatr Surg Int. 2006 May;22(5):462-4. Epub 2006 Feb 4.
PMID: 16463034 [PubMed - indexed for MEDLINE]
Related Articles

 

23:

Gastrointestinal tumors in children and adolescents.

 

Ladd AP, Grosfeld JL.
Semin Pediatr Surg. 2006 Feb;15(1):37-47.
PMID: 16458845 [PubMed - indexed for MEDLINE]
Related Articles

 

24:

[Gastric stromal tumor in childhood--a rare diagnosis with an initial consideration of Hodgkin's disease]

 

Kau W, Stessel U, Schoellnast H.
Rofo. 2006 Jan;178(1):112-4. German. No abstract available.
PMID: 16392067 [PubMed - indexed for MEDLINE]
Related Articles

 

25:

Multiple gastric stromal tumors in a child without syndromic association lacks common KIT or PDGFRalpha mutations.

 

O'Sullivan MJ, McCabe A, Gillett P, Penman ID, MacKinlay GA, Pritchard J.
Pediatr Dev Pathol. 2005 Nov-Dec;8(6):685-9. Epub 2005 Nov 18.
PMID: 16328663 [PubMed - indexed for MEDLINE]
Related Articles

 

26:

Advanced-stage gastrointestinal stromal tumor treated with imatinib in a 12-year-old girl with a unique mutation of PDGFRA.

 

Kuroiwa M, Hiwatari M, Hirato J, Suzuki N, Tsuchida Y, Shimada A, Shitara T, Taki T, Hayashi Y.
J Pediatr Surg. 2005 Nov;40(11):1798-801.
PMID: 16291174 [PubMed - indexed for MEDLINE]
Related Articles

 

27:

Gastrointestinal stromal tumor in a child and review of the literature.

 

Hayashi Y, Okazaki T, Yamataka A, Yanai T, Yamashiro Y, Tsurumaru M, Kajiyama Y, Miyano T.
Pediatr Surg Int. 2005 Nov;21(11):914-7. Review.
PMID: 16240136 [PubMed - indexed for MEDLINE]
Related Articles

 

28:

Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up and review of the literature.

 

Miettinen M, Lasota J, Sobin LH.
Am J Surg Pathol. 2005 Oct;29(10):1373-81.
PMID: 16160481 [PubMed - indexed for MEDLINE]
Related Articles

 

29:

[Carney triad; report of a case]

 

Mori S, Yoshioka H, Fukui T, Usami N, Uchiyama M, Sato N, Ito M, Kaji M, Ueda Y.
Kyobu Geka. 2005 Jul;58(7):597-601. Review. Japanese.
PMID: 16004346 [PubMed - indexed for MEDLINE]
Related Articles

 

30:

Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature.

 

Prakash S, Sarran L, Socci N, DeMatteo RP, Eisenstat J, Greco AM, Maki RG, Wexler LH, LaQuaglia MP, Besmer P, Antonescu CR.
J Pediatr Hematol Oncol. 2005 Apr;27(4):179-87. Review.
PMID: 15838387 [PubMed - indexed for MEDLINE]
Related Articles

 

31:

Gastrointestinal stromal tumor (GIST) of stomach in a pediatric patient.

 

Egloff A, Lee EY, Dillon JE.
Pediatr Radiol. 2005 Jul;35(7):728-9. Epub 2005 Mar 31. No abstract available.
PMID: 15800780 [PubMed - indexed for MEDLINE]
Related Articles

 

32:

[Stromal gastrointestinal tumors in children: about a case]

 

Dijoud F, Frachon S, Basset T, Bertrand Y, Bergeron C.
Ann Pathol. 2004 Dec;24(6):628-31. French.
PMID: 15785409 [PubMed - indexed for MEDLINE]
Related Articles

 

33:

A case of pediatric gastrointestinal stromal tumor of the stomach.

 

Iwasaki M, Morimoto T, Sano K, Fukumitsu K, Takeda R, Iwata S, Nakamura Y, Yasui H, Urata Y, Mukaihara S.
Pediatr Int. 2005 Feb;47(1):102-4. Review. No abstract available.
PMID: 15693878 [PubMed - indexed for MEDLINE]
Related Articles

 

34:

Gastrointestinal stromal tumour of the colon presenting with intestinal obstruction.

 

Gupta S, Punia RS, Kaushik R.
Indian J Cancer. 2004 Oct-Dec;41(4):175-7. Review.
PMID: 15659872 [PubMed - indexed for MEDLINE]
Related Articles Free article at journal site

 

35:

Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up.

 

Miettinen M, Sobin LH, Lasota J.
Am J Surg Pathol. 2005 Jan;29(1):52-68.
PMID: 15613856 [PubMed - indexed for MEDLINE]
Related Articles

 

36:

Gastrointestinal stromal tumour of the duodenum in a 7-year-old boy.

 

Hughes JA, Cook JV, Said A, Chong SK, Towu E, Reidy J.
Pediatr Radiol. 2004 Dec;34(12):1024-7. Epub 2004 Oct 15.
PMID: 15490151 [PubMed - indexed for MEDLINE]
Related Articles

 

37:

Gastrointestinal stromal tumors arising from the stomach: a report of three children.

 

Durham MM, Gow KW, Shehata BM, Katzenstein HM, Lorenzo RL, Ricketts RR.
J Pediatr Surg. 2004 Oct;39(10):1495-9.
PMID: 15486893 [PubMed - indexed for MEDLINE]
Related Articles

 

38:

Separate occurrence of extra-adrenal paraganglioma and gastrointestinal stromal tumor in monozygotic twins: probable familial Carney syndrome.

 

Boccon-Gibod L, Boman F, Boudjemaa S, Fabre M, Leverger G, Carney AJ.
Pediatr Dev Pathol. 2004 Jul-Aug;7(4):380-4. Epub 2004 Jul 15.
PMID: 15383933 [PubMed - indexed for MEDLINE]
Related Articles

 

39:

Biology of gastrointestinal stromal tumors.

 

Corless CL, Fletcher JA, Heinrich MC.
J Clin Oncol. 2004 Sep 15;22(18):3813-25. Review.
PMID: 15365079 [PubMed - indexed for MEDLINE]
Related Articles

 

40:

Infantile intestinal leiomyosarcoma is prognostically favorable despite histologic aggressiveness: case report and literature review.

 

Yamamoto H, Tsuchiya T, Ishimaru Y, Kisaki Y, Fujino J, Uchida H, Yoshida M, Mori Y, Ikeda H.
J Pediatr Surg. 2004 Aug;39(8):1257-60. Review.
PMID: 15300540 [PubMed - indexed for MEDLINE]
Related Articles

 

41:

Pediatric gastrointestinal stromal tumors and leiomyosarcoma.

 

Cypriano MS, Jenkins JJ, Pappo AS, Rao BN, Daw NC.
Cancer. 2004 Jul 1;101(1):39-50.
PMID: 15221987 [PubMed - indexed for MEDLINE]
Related Articles Free article at journal site

 

42:

Soft tissue sarcomas. Case 3. Gastrointestinal stromal tumor and Carney's triad.

 

Spatz A, Bressac-de-Paillerets B, Raymond E.
J Clin Oncol. 2004 May 15;22(10):2029-31. No abstract available.
PMID: 15143098 [PubMed - indexed for MEDLINE]
Related Articles

 

43:

[A child with gastric stromal sarcoma]

 

Zhou SM, Sun LB, Luo HY, Wei JR, Bai DM.
Zhonghua Er Ke Za Zhi. 2004 Jan;42(1):73. Chinese. No abstract available.
PMID: 14990115 [PubMed - indexed for MEDLINE]
Related Articles

 

44:

Gastric stromal tumors in children.

 

Haider N, Kader M, Mc Dermott M, Devaney D, Corbally MT, Fitzgerald RJ.
Pediatr Blood Cancer. 2004 Feb;42(2):186-9.
PMID: 14752885 [PubMed - indexed for MEDLINE]
Related Articles

 

45:

[Stromal tumor of the stomach in a 14 year old girl]

 

Budzyński A, Stachura T, Ostrowska M, Zasada J, Grochowska E.
Przegl Lek. 2003;60 Suppl 7:81-5. Polish.
PMID: 14679701 [PubMed - indexed for MEDLINE]
Related Articles

 

46:

Pathology teach and tell: pediatric gastrointestinal stromal tumor.

 

Sebire NJ, Ramsay A, Malone M, Risdon R.
Pediatr Pathol Mol Med. 2003 May-Jun;22(3):259-64. No abstract available.
PMID: 12746177 [PubMed - indexed for MEDLINE]
Related Articles

 

47:

Epithelioid gastrointestinal stromal tumor of the stomach with liver metastases in a 12-year-old girl: aspiration cytology and molecular study.

 

Li P, Wei J, West AB, Perle M, Greco MA, Yang GC.
Pediatr Dev Pathol. 2002 Jul-Aug;5(4):386-94. Epub 2002 Jun 17.
PMID: 12198577 [PubMed - indexed for MEDLINE]
Related Articles

 

48:

An unusual case of complete Carney's triad in a 14-year-old boy.

 

Wales PW, Drab SA, Kim PC.
J Pediatr Surg. 2002 Aug;37(8):1228-31.
PMID: 12149713 [PubMed - indexed for MEDLINE]
Related Articles

 

49:

Typical and atypical Carney's triad presenting with malignant hypertension and papilledema.

 

Valverde K, Henderson M, Smith CR, Tallett S, Chan HS.
J Pediatr Hematol Oncol. 2001 Nov;23(8):519-24.
PMID: 11878780 [PubMed - indexed for MEDLINE]
Related Articles

 

50:

A huge gastric stromal tumor in a 13-year-old girl.

 

Oğuzkurt P, Akçören Z, Senocak ME, Cağlar M, Büyükpamukçu N.
Turk J Pediatr. 2002 Jan-Mar;44(1):65-8.
PMID: 11858384 [PubMed - indexed for MEDLINE]
Related Articles

 

51:

Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney triad.

 

Carney JA, Stratakis CA.
Am J Med Genet. 2002 Mar 1;108(2):132-9.
PMID: 11857563 [PubMed - indexed for MEDLINE]
Related Articles

 

52:

Congenital gastrointestinal stromal tumour is morphologically indistinguishable from the adult form, but does not express CD117 and carries a favourable prognosis.

 

Bates AW, Feakins RM, Scheimberg I.
Histopathology. 2000 Oct;37(4):316-22. Review.
PMID: 11012738 [PubMed - indexed for MEDLINE]
Related Articles

 

53:

Clinical and histopathological features of colonic stromal tumor in a child.

 

Terada R, Ito S, Akama F, Kidogawa H, Ichikawa K, Ooe H.
J Gastroenterol. 2000;35(6):456-9.
PMID: 10864354 [PubMed - indexed for MEDLINE]
Related Articles

 

54:

Primary leiomyosarcoma arising from the greater omentum in a 15-year-old girl.

 

Niwa K, Hashimoto M, Hirano S, Mori H, Tamaya T.
Gynecol Oncol. 1999 Aug;74(2):308-10.
PMID: 10419753 [PubMed - indexed for MEDLINE]
Related Articles

 

55:

Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adrenocortical component, and possible familial occurrence.

 

Carney JA.
Mayo Clin Proc. 1999 Jun;74(6):543-52.
PMID: 10377927 [PubMed - indexed for MEDLINE]
Related Articles

 

56:

Gastrointestinal autonomic nerve tumors in the pediatric population: a report of four cases and a review of the literature.

 

Kerr JZ, Hicks MJ, Nuchtern JG, Saldivar V, Heim-Hall J, Shah S, Kelly DR, Cain WS, Chintagumpala MM.
Cancer. 1999 Jan 1;85(1):220-30. Review.
PMID: 9921996 [PubMed - indexed for MEDLINE]
Related Articles Free article at journal site

 

57:

Association of gastrointestinal stromal tumor (leiomyosarcoma), pulmonary chondroma, and nonfunctional retroperitoneal paraganglioma.

 

Mendes W, Ayoub A, Chapchap P, Antoneli CB, Sredni ST, de Camargo B.
Med Pediatr Oncol. 1998 Dec;31(6):537-40. No abstract available.
PMID: 9835913 [PubMed - indexed for MEDLINE]
Related Articles

 

58:

Immunohistochemical localization of acidic fibroblast growth factor in normal human enterochromaffin cells and related gastrointestinal tumours.

 

La Rosa S, Chiaravalli AM, Capella C, Uccella S, Sessa F.
Virchows Arch. 1997 Feb;430(2):117-24.
PMID: 9083514 [PubMed - indexed for MEDLINE]
Related Articles

 

59:

Gastric autonomic nerve (GAN) tumor and extra-adrenal paraganglioma in Carney's triad. A common origin.

 

Tortella BJ, Matthews JB, Antonioli DA, Dvorak AM, Silen W.
Ann Surg. 1987 Mar;205(3):221-5.
PMID: 3827356 [PubMed - indexed for MEDLINE]
Related Articles Free article in PMC

 

60:

Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib

 

Janeway KA, Albritton KH, Van Den Abbeele AD, D'Amato GZ, Pedrazzoli P, Siena S, Picus J, Butrynski JE, Schlemmer M, Heinrich MC, Demetri GD.
Pediatr Blood Cancer. 2009 Mar 26. [Epub ahead of print]
PMID: 19326424 [PubMed - as supplied by publisher]

Related Articles